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Placental hypoxia or ischemia among preeclampsia patients is thought to be the cause of the formation of free radicals such as malondialdehyde (MDA), which decreases endogenous antioxidants such as glutathione (GSH)

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Furthermore, aging leads to reduced transcription of OCTN2 mRNA [87], the l-carnitine transporter, indicating that tissue distribution and homeostasis of l-carnitine is hampered with advanced age