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stratifying by metabolic status, by genetic risk such as GBA and LRRK2 variants in Parkinsons or APOE in Alzheimers, by disease stage, and potentially by GLP-1R polymorphism is the most plausible route to a positive trial

The body's metabolic rate exists within a carefully regulated physiological range, and disrupting this balance without medical supervision may result in fatigue, muscle loss, and metabolic disorders

Although small molecules, such as polyphenols, in food have been found to activate GPCRs 12,13,14 , the specific ligandreceptor combinations are poorly understood

The majority of serine catabolism involves its conversion to glycine, followed by glycine decarboxylase-mediated metabolism as detailed in the Amino Acid Catabolism page