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To further validate the above discovery, the authors designed two structurally similar fentanyl derivatives FBD1 (partial agonist) and FBD3 (full agonist), with the aim to obtain OR agonists with reduced/abolished -arrestin signaling but relatively intact G protein activity (Figure 6a)

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doi: 10.1038/s41467-023-35795-8 11 CzubaLCHillgrenKMSwaanPW

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Intoxications over the 450 line (green line below): third dose of 18.75 mg/kg/hr (triple the standard dose)

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Dosing appears to play a role some trials have shown antioxidant effects with 800mg/day, while others suggest stronger responses at 1,2002,400mg/day, particularly for lowering oxidative stress biomarkers in patients with multiple sclerosis.3 28 Keep in mind, though: while higher doses (typically 1,2002,400mg per day) may offer stronger antioxidant effects, they also come with a greater chance of side effects like upset stomach or dizziness

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