Positively charged and metal-doped CQDs show heightened oxidative and inflammatory responses, while negatively charged or hydrophilic CQDs remain generally safe
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Compared with other forms of cell death such as apoptosis, necrosis, and autophagy, ferroptosis exhibits distinct molecular mechanisms and biological features ( Table 1 ): (1) Iron Dependence: Ferroptosis is uniquely triggered by elevated intracellular iron levels, differentiating it from other cell death modes
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In the presence of inflammation, alterations in intestinal barrier function, along with increased intestinal permeability and bacterial translocation, can trigger IBD and autoimmunity in genetically predisposed individuals [68, 69]
