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"Human dopamine beta-hydroxylase promoter variant alters transcription in chromaffin cells, enzyme secretion, and blood pressure"

Metformin, involved in the metabolic reprogramming of tumor cells, can downregulate glycolysis and inhibit cancer growth, but its therapeutic efficacy is limited in hypoxic microenvironments ( 4.4 Autophagy-mediated ferroptosis Plant polysaccharides can enhance ferroptosis against cancer by activating autophagy pathways, causing ferritin degradation and Fe 2+ accumulation

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A 2022 study in Frontiers in Pharmacology reported absorption, distribution, metabolism, and excretion data for the compound in rats and dogs, providing one of the first structured pharmacokinetic profiles in the peer-reviewed record [7]

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