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A reduction of the N-terminal peptide bond of 25 , with the ambition to achieve a compound even more resistant to proteolytic cleavage, provided 26 ( 26 displays a Ki value in the micromolar range in sharp contrast to what could be expected considering the results obtained after reduction of Ang IV or Nle-Ang IV, cf

BPC-157s pharmaceutical analogue PL 14736 is under development, and if it reaches randomized controlled trials with positive outcomes, it will substantially reframe this class of compound

doi: 10.1002/adhm.202303995 125 ZhangXJozicASongPXuQShiXWangHet al

[DOI] [PubMed] [Google Scholar] 227

Why each feature matters: Doubling time is a standard clinical metric