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These older weight loss drugs have been popularly used for weight loss for longer than GLP-1 receptor agonists

Some patients find it helpful to take semaglutide in the evening or at night, as this allows them to sleep through the initial period when nausea can be most pronounced

[DOI] [PubMed] [Google Scholar] 194.Benson JM, Peritt D, Scallon BJ, Heavner GA, Shealy DJ, Giles-Komar JM, et al

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It is important to note, however, that much of the mechanistic knowledge underlying these processes comes from experimental obesity/T2DM models, while evidence in humans remains more limited and often based on systemic endpoints