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in Nature Medicine found that NNMT inhibition in white adipose tissue increased energy expenditure and reduced fat mass in animal models without altering food intake or physical activity (Kraus et al., Nature Medicine )

Such findings have been confirmed by a systematic review and meta-analysis in which 6 randomized clinical trials were included in the analysis (167)

the 0.1 mg/ml or 2 mg/ml 2PAB solution was prepared from a 100 mg/ml stock with appropriate dilution with 0.9% saline

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