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308,309,310,311,312 This may be explained by the fact that an increased risk of HF may be related to fluid retention, which suggests that this change is reversible

Trials of Safety and Efficacy There is now extensive research concerning the efficacy and general safety of the first four DPP-4 inhibitors: sitagliptin, linagliptin, vildagliptin and saxagliptin

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