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To date, niacinamide, ascorbic acid, resveratrol, azelaic acid, and kojic acid are considered alternative topical agents that have been reported to exhibit depigmenting properties without severe adverse effects

ii) increased AMPK also inhibits mitochondrial glycerol-3-phosphate dehydrogenase (mGPD), leading to an increase in cytosolic NADH, which both stimulates the conversion of pyruvate to lactate, and simultaneously decreases gluconeogenesis

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