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Moreover, Lactobacillus rhamnosus GG, a common intestinal bacterium, was successfully co-cultured on the luminal surface of the intestinal epithelium, without compromising epithelial cell viability

The treatment of the subjects of group 3, the TRX2 supplement and lotion group, included the treatments of group 1 and 2

564 HO-1 and GPX4 were downregulated due to Nrf2 defects in astrocytes, leading to increased mitochondrial fragmentation, DNA oxidation, and lipid peroxidation in mouse astrocytes, 564 suggesting that Nrf2 deficiency promotes ferroptosis in astrocytes in AD mice

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The mechanism is homocysteine accumulation during the early adaptation phase