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The reduction of lipotoxicity led to improvements in fibrosis stage, collagen, plasma Pro-C3, and plasma ALT but not liver fat

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Endothelial injury generated directly by intracellular viral replication and by ACE2 downregulation, exposing cells to angiotensin II in the absence of the modulator effects of angiotensin 17 (270, 271), and vascular chronic inflammation promoting the development of tissue macrophages overloaded by cholesterol (foam cells), both increase the possibility of acquiring a severe COVID-19 infection (170, 209, 258, 259, 272, 273)

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A particularly fascinating aspect of reactive microglia in neurodegeneration is their dynamic receptor expression profilewhile these receptors are nearly undetectable in resting microglia, they become markedly upregulated upon activation

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