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Documentation and tracking Keep a simple log for each vial: reconstitution date, water volume added, concentration, and a running tally of doses drawn with dates

It was originally approved for the treatment of type 2 diabetes by the FDA in May 2022 under the brand name Mounjaro, and then, in response to the significant weight loss results during clinical trials, the FDA approved tirzepatide in November 2023 for chronic weight management under the name Zepbound

More recently, novel co-agonists of GLP-1, glucose-dependent insulinotropic polypeptide (GIP) and glucagon have also been approved or are under evaluation for the treatment of diabetes and associated metabolic diseases, holding potential for cardiovascular risk reduction

[20] [5] For NHS-funded treatment, continuation criteria apply, and treatment is typically limited to a maximum of 2 years

FoxO1-deficient -cells lose their identity and revert to pancreatic endocrine progenitors characterized by expressing high levels of neurogenin-3 (Neurog3 high ), and no insulin and MafA expression 22