Detailed biological characteristics of GLP-1 and proposed modes of action of GLP-1RAs on the metabolic and CV systems have been investigated in preclinical and clinical studies and summarized elsewhere [7,8,9,10,11,12]
doi:10.1016/j.dsx.2017.04.017
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Its core pathophysiological characteristics are intricately intertwined with abnormal iron and lipid metabolism, oxidative stress, mitochondrial dysfunction, and neuroinflammation, driving the progressive degeneration of dopaminergic neurons in the substantia nigra (SN) ( Figure 2 )
This is where glutathione becomes a hero rather than a culprit