Glutathione synthesis can be impaired by cysteine depletion, protein-energy malnutrition, hyperglycemia, glucocorticoid at pharmacologic doses, and decreased secretion of anterior pituitary hormones (growth hormones, thyrotropin, gonadotropins), as often observed in prolonged critical illness
APAP hepatotoxicity occurs through formation of the noxious NAPQI metabolite, which is present in excessive quantities, as augmented by features of glutathione (GSH) depletion, oxidative stress and mitochondrial dysfunction leading to depletion in adenosine triphosphate (ATP) stores
Thus, a drug delivery method and protocol would need to be developed for the Nrf2 inhibitor to preferentially target cancer cells
Es gibt jedoch Zeiten, in denen der Glutaminbedarf Deines Krper grer ist und er nicht die ausreichende Menge Glutamin produziert
Ann Thorac Surg:266-267, 2003