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Additionally, research in the EAE model has found that KD can inhibit the GSDMD and JAK2-STAT3/4 pathways, decrease T cell migration and infiltration into the CNS, promote Treg cell differentiation, and decrease Th17 cell differentiation in the spleen and spinal cord (287), providing new therapeutic approaches for MS

While this symptom is not listed as a primary side effect in major trials, emerging reports suggest it may occur in a subset of users

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In SURMOUNT-1, adults with obesity (without diabetes) lost an average of 15.0%, 19.5%, and 20.9% of body weight with tirzepatide 5 mg, 10 mg, and 15 mg respectively over 72 weeks, compared to 3.1% with placebo