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423 The atherogenic, proinflammatory and prothrombotic properties of Lp(a) contribute to its role in ASCVD pathogenesis 424 Notably, 7090% of the serum Lp(a) concentration is genetically determined by the expression of the LPA gene 425,426 and is largely unaffected by diet and lifestyle modifications

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Nevertheless, in streptozotocin-induced type 1 diabetes, 11 integrin was observed to mediate not only myocardial fibrosis but also significant matrix-preserving actions that safeguard the heart against dysfunction[144], thereby highlighting its dual role in mediating fibrotic remodeling and myocardial preservation during the progression of diabetic heart disease