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Lancet Diabetes Endocrinol 6(4):275286 Rossing P, Baeres FMM, Bakris G, Bosch-Traberg H, Gislum M, Gough SCL et al (2023) The rationale, design and baseline data of FLOW, a kidney outcomes trial with once-weekly semaglutide in people with type 2 diabetes and chronic kidney disease

Among patients without diabetes, GLP-1 use was associated with a 34% lower risk of fracture for those with osteopenia and a 38% lower risk for those with osteoporosis

It works through multiple mechanisms AMPK activation and bitter taste receptor pathways in the gut and a meta-analysis of 37 RCTs confirms meaningful glucose-lowering effects

Ferreira MP, et al

Focus on compound movements that work multiple muscle groups at once