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Effects of prolonged strenuous exercise (marathon running) on biochemical and haematological markers used in the investigation of patients in the emergency department

Desensitization and Receptor Trafficking Most agonist-activated GPCRs undergo rapid desensitization through a coordinated two-step process: first, phosphorylation of the receptor by GRKs, and second, recruitment of -arrestins to these phosphorylated sites, which sterically block further G-protein coupling [54]

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Whereas antibody-based therapeutics directly bind the protein of interest, ASOs target the protein by altering its gene expression