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The gene silencing of ACSL4 in primary microglial cells has been reported to impede ferroptosis of microglia induced by HIV-1 Tat protein, with an effect comparable to that of the administration of Fer-1 or DFO ( Figure 3 )

If irritation is persistent or severe, reducing dose or frequency may help

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They noted that unmeasured lifestyle and dietary factors may have influenced results, but concluded that clinicians should remain alert to reflux symptoms in patients starting GLP-1 RAs