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Subfamilies and isoforms can be categorized based on the sequence similarity, domain architecture, quaternary structure, enzymatic activity, ironsulfur cluster binding and the number of active site cysteine residues 1,2,3,4,5

But then the, the broader body of literature, I mean, supports that observation

Liraglutide, a glucagon-like peptide-1 analog, induce autophagy and senescence in HepG2 cells