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A study utilized 1H-MRS and resting-state functional magnetic resonance imaging to investigate metabolic changes throughout the migraine cycle and their relationship to functional connectivity

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Vehicle treated obese/T2D (n=20), and lean (n=18) mice were used as controls.Stroke was induced by 35-minute transient middle cerebral artery occlusion 72 hours after the last treatment to avoid potential acute neuroprotective effects of the drugs

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In clinical trials, participants achieved an average of 8.5 percent body weight loss by week 24 at the 8 mg dose, with results accelerating through week 48