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Others may need a medication taper, a lower maintenance dose, hormone evaluation, or additional testing

It should include nutrition, physical activity, lab monitoring, blood pressure checks, cholesterol review, sleep evaluation, and follow-up visits

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While lifestyle changes, notably dietary fructose reduction, remain the primary treatment for MAFLD, emerging approaches including liver-gut axis targeting involving microbiome adjustments hold promise

In this phase 3 clinical trial, some participants reported side effects, including mild to moderate nausea and diarrhea, but these side effects are short-lived and can usually be resolved without the need to terminate the trial permanently