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After alignment of the image stack, images were processed using destriping (ZEN) based on the VSNR algorithm 107

For the analytical value (parts per billion [ppb]) of each organ, the value corrected with the cutoff value was adopted as the hydrogen volume contained in each tissue

Apoptosis inhibitor of macrophage (AIM), also called CD5 antigen-like (CD5L), is a 36 kDa soluble protein that belongs to the SRCR superfamily Group B with three head-to-tail linked SRCR domains, mainly expressed by tissue-resident macrophages in the liver as well as lymphoid and inflamed tissues 3,4

While these observational data cannot definitively establish causality and may be subject to residual confounding despite sophisticated analytical approaches, the consistency of findings across multiple large, geographically diverse cohorts using different methodologies substantially strengthens confidence in the hepatoprotective benefits of GLP-1-based therapies

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