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In addition, measurement of expression of URA3 in the pGSH1-URA3 strain according to levels of GFP-tagged Ura3 revealed a significant upregulation by 5-FOA (Figure S4C)

362 NAD + deficiency correlates with disturbed circadian clocks during aging Besides mitigating the oxidative damage, NAD + can extend lifespan by driving the circadian rhythms

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