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Description

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Computational approaches in this domain included: Physiologically-based pharmacokinetic (PBPK) modeling Blood-brain barrier permeability prediction Metabolic stability simulation In silico toxicity assessment Drug-drug interaction prediction These computational predictions helped researchers prioritize compounds with optimal pharmacokinetic profiles before investing in expensive animal studies and clinical trials

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Neuropsychopharmacology 39:17771785 Hashimoto R, Nagatsu T, Ohta T, Mizutani M, Omura I (2004) Changes in the concentrations of tetrahydrobiopterin, the cofactor of tyrosine hydroxylase, in blood under physical stress and in depression

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