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We further conducted detailed whole-worm lipidomic, intestinal-specific transcriptomic, and genetic interaction analyses using three representative strains, the germline-less glp-1(e2144) , the feminized fem-3(e1996) and the masculinized mog-3(q74)

The findings challenge a longstanding clinical gap: despite type 2 diabetes being recognized as a cardiovascular risk equivalent for decades, intensive lipid-lowering has historically been reserved for patients with a prior heart attack or stroke