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revealed that RA patients often exhibit increased insulin resistance

278 Muscle, Adipose Tissue and Liver Given the ability of GLP-1 to promote the incretin effect, 11,107 this hormone has indirect actions on tissues such as skeletal muscle, adipose tissue and the liver through insulin- insulin acts as a second messenger of GLP-1

To investigate whether the metabolic effects of mGIPR-Ab/GLP-1 are similar in female mice, we treated female HFD-fed Glp1r fl/fl control and Glp1r Wnt1/ mice with IP injection of either vehicle or mGIPR-Ab/P1 every 6 days for 18 days

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