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GLP-1 has been shown to attenuate meal-induced gastric antral propagated contractions while increasing pyloric tone (159, 160)

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The efficacy of IDegLira (insulin degludec/liraglutide combination) in adults with type 2 diabetes inadequately controlled with a GLP-1 receptor agonist and oral therapy: DUAL III Randomized Clinical Trial

These developments align with the general trend of IGF pharmacology toward finer allosteric modulators, conceptual heirs of lessons learned from previous clinical failures.

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