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As manufacturing technology improves, prices generally trend downward over time

We found a beneficial effect of vitamin B 12 supplementation for 6 months on neurodevelopment in young North Indian children.16 In this study, where the children were supplemented daily with two recommended daily allowances (RDA) for 6 months, the effect of vitamin B 12 supplementation was more apparent in children who had evidence of vitamin B 12 deficiency at the start of the study

I generally recommend starting with the lower dose of 0.25 mg for the first week before considering increases

For most wellness goals, the practical difference is small

Oncogene 30 , 13181328 (2011)