In prostate and bladder cancer, the Gln metabolism antagonist JHU083 inhibits TAM Gln metabolism, resulting in increased glycolysis, disruption of the tricarboxylic acid (TCA) cycle, and impairment of purine metabolism
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Similar results were reported in mice treated with GLP-1/dexamethasone, an unimolecular peptide-nuclear hormone conjugate designed to optimize dexamethasone delivery into GLP-1R positive cells [820]
Serious but less common adverse effects include pancreatitis, gallbladder disease, acute kidney injury (particularly in the setting of dehydration from gastrointestinal symptoms), and hypoglycemia when used in combination with insulin or sulfonylureas
TB-500 also supports sperm production through improved testicular blood flow