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Utilizing PHTPP, a selective ESR2 antagonist, the authors demonstrate that the therapeutic benefits of exercise are largely reliant on the ESR2-mediated signaling system, therefore providing novel insights into the processes governing exercise treatment for KOA [110]

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Duan X, Li X, Lou H, Geng T, Jin T, Liang P, Li S, Long Y, Chen C

Cell 187 , 235256 (2024)

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