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doi: 10.3389/fendo.2022.920541 Received 14 April 2022 Accepted 19 August 2022 Published 08 September 2022 Volume 13 - 2022 Edited by Rishi Raj, Pikeville Medical Center, United States Reviewed by Sudhanshu Kumar Bharti, Patna University, India

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Although GIP receptor activation may exert anti-emetic effects through brainstem modulation, these effects appear insufficient to completely counterbalance GLP-1 mediated emesis during early treatment and dose escalation ( In contrast, glucagon receptor activation is independently associated with nausea and vomiting through both central and peripheral mechanisms, including effects on gastric motility and autonomic signaling

IM injections may require a longer needle and careful site placement but are still practical with proper guidance

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