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SILY alone or co-administered with SERT reduced the changes in locomotor activity, rearing, and grooming observed in mice administered with DEX alone

Treatment of 4.2 / mice with mitapivat was also associated with a trend toward a decrease in splenic erythropoietic activity and a significant reduction in BM erythropoiesis (Supplemental Figure 4, C and D)

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It works at the tissue signaling level, which means it supports and amplifies other aesthetic and regenerative treatments rather than replacing them

References Agnes WB, Carmen V, Catrin A, Roger B, Marie JD, Sandra MHC, Aalt B, Martin R, Leonie J, Frederik-Jan VS, Roel PFS (2020) The dietary antioxidant quercetin reduces hallmarks of bleomycin-induced lung fibrogenesis in mice