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Several factors can cause glutathione deficiency, such as poor nutrition, exposure to environmental toxins, chronic stress, and the natural aging process

MARK kinases, members of the AMPK-related kinase family, potentiate the AMPK1/mTOR/HIF-1 signaling axis, contributing to the Warburg effect and cell proliferation in non-small cell lung cancer (60)

This is also seen in hepatic coma, hyperthyroidism, myocardial infarction, megaloblastic anemia, and chronic blood loss

Cecchini R, Cecchini AL (2020) SARS-CoV-2 infection pathogenesis is related to oxidative stress as a response to aggression