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The insula, for example, is reliably activated during threat anticipation (Sambuco, Costa, et al., 2020b, 2020a) but less so during free viewing of emotional images, where inferior frontal gyrus (IFG) activation near opercular regions may be the primary driver (Sambuco, Bradley, et al., 2020), and spatial smoothing could misattribute these effects to the adjacent insula

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The collagen is extracted by boiling skin, bones, scales, or cartilage, and then hydrolyzedbroken down enzymaticallyto create smaller peptides that are more easily absorbed by the body (Liu, 2015)

For weight loss, this mechanism is beneficial, but for IBS patients, it introduces a variable that can either help or complicate existing symptoms