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Years later, symptoms can include chronic headaches, cognitive decline, mood disorders, memory loss, seizures and persistent neurological issues
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Nevertheless, pathways implicated in preclinical studies, including angiogenesis, inflammatory modulation, and collagen remodeling, intersect with biologic systems central to incision healing and complication avoidance, although these mechanistic signals have not been shown to translate into improved clinical outcomes
2017;26:884896.e885
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