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Y.et al (2024)

Overexpression of S100a3 (which is found to be increased in both gene sequencing and qPCR analysis), a protein involved in keratinocyte maturation, further supports the idea that GLP-1 exposure disturbs normal skin formation

The inner ring illustrates key downstream signaling pathwaysincluding cAMP/PKA, Epac/PI3K/Akt, AMPK/SIRT1, and ERK/MAPKthat orchestrate mitochondrial biogenesis, antioxidant defenses, proteostasis, autophagy, stress adaptation, and regulation of inflammation

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Unfortunately, as we age or develop conditions like osteoarthritis, our bodies produce less hyaluronic acid