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The near-infrared II (NIR-II) area photothermal therapy (PTT) performance of HAuNS@PEG-bio is demonstrated to be effective, and the elevation of temperature at the tumor site stimulates blood circulation to mitigate the hypoxia within the tumor microenvironment (TME) (159)

3-Hydroxy-3-methylglutaryl-CoA lyase deficiency is a disorder biochemically characterized by the predominant accumulation of 3-hydroxy-3-methylglutarate (HMG), 3-methylglutarate (MGA), 3-methylglutaconate and 3-hydroxyisovalerate in tissues and in vivo administration of HMG and MGA significantly decrease GSH concentration in liver in young rats [25]