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Cons of a Systemic Approach: Lower Local Concentration: The peptide is distributed throughout the body, so the concentration reaching the plantar fascia will be lower than with a direct, local injection

However, a posterior analysis done specifically in those methylcobalamin-treated patients who were diagnosed and started the study earlier (a year or less after symptom onset) showed that methylcobalamin exhibited efficacy, or a trend towards efficacy

This is harder on GLP-1s because your appetite is suppressedyou need to prioritize protein even when you don't feel like eating

A research vial usually is not

As a research tool without commercial pharmaceutical development, this investment has not been made