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These include some heartburn medicines, including esomeprazole (Nexium), famotidine (Pepcid AC), lansoprazole (Prevacid), omeprazole (Prilosec OTC), pantoprazole (Protonix), rabeprazole (Aciphex), as well as some diabetes, gout, and chemotherapy drugs

Indeed, the ability of serine to be synthesized from the glycolytic intermediate, 3-phosphoglycerate, directly ties glucose metabolism to the active THF pool

On top of that, any NAD+ that your cells do have left gets used up faster in response to stress, illness, or environmental damage

Chen JS, Wang ST, Mei Q et al (2024) The role of CBLCIPK signaling in plant responses to biotic and abiotic stresses

Mann et al., 1983