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Novo Nordisk lost patent protection for the drug in January, stemming from an error in paying a small patent maintenance fee in the nation, as originally reported by Endpoints News in 2025

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The FDA classifies phentermine as a Schedule IV controlled substance due to its stimulant properties and potential for dependence, though actual addiction rates remain low when the medication is used as prescribed

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Interestingly, extracellular 13-HODE was reported to induce mitochondrial dysfunction and airway epithelial apoptosis, which was associated with its interaction with the transient receptor potential cation channel, vanilloid type 1 (TRPV1) receptor 59