In one study, individuals who lost 510% of their body weight reported significant improvements in back pain and mobility
To add on to things, I developed blood clots in my legs which led to even more immobility & depression, plus I was in nursing school at the time
[DOI] [PMC free article] [PubMed] [Google Scholar] 61.Nuijten M.A.H., Eijsvogels T.M.H., Monpellier V.M., Janssen I.M.C., Hazebroek E.J., Hopman M.T.E
Eur J Pharmacol 1981
In phase I reactions, CYP1A1/2 and CYP3A4 oxidise estrogen to a 2-hydroxylated catechol estrogen, whereas CYP1B1 (which is constitutively expressed in the breasts, ovaries, adrenal glands, and uterus, as well as in several other tissues 13,14 converts it to 4-hydroxylated catechol estrogen 15,16