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Our CLP model showed chronic Nrf2/HO-1/GPX4 suppression (day 7) linked to GSH depletion, ferroptosis, and irreversible antioxidant collapse ( + precursor) in SAE hippocampi
However, avoid taking it simultaneously with iron supplements, as antioxidants may interfere with iron absorption
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In studies of GPX5 knockout mice, we deduced that GPX5 is a way to maintain the integrity of sperm DNA function by removing excess H 2 O 2 , and these mice did not exhibit significant defects in the epididymis and sperm cells ( 2 O 2 scavengers was detected (Noblanc et al., 2012), proving that after SNGPX4 and GPX5 double knockouts, the epididymal tissues of mice produced oxidative stress responses, indicating that SNGPX4 and GPX5 play a role in maintaining the normal structure of the sperm nucleus in the epididymal tissue (Noblanc et al., 2012)
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