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Most patients experience mild nausea during the first 12 weeks at each new dose level, which usually resolves as your body adapts to increased GLP-1 and GIP signaling

For a broader overview of the hormone pathway behind this class of treatment, see our guide on how GLP-1 works for weight loss

What sets retatrutide apart is its triple agonist approach, which means it acts on three hormone pathways in your body at the same time: GLP-1, GIP, and glucagon

8 Safety data Conventional chemotherapeutic drugs such as paclitaxel, fluorouracil, tamoxifen, and raloxifene are a few commonly used chemo-preventive medications