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Additionally, stress-induced hormonal changes, characterized by an increase in cortisol levels, have been linked to the acceleration of premature greying by affecting melanocyte stem cells

Oxidative Medicine and Cellular Longevity, 2012 , 324832

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240 It has also been shown that MTA accumulation and secretion occur in MTAP-deficient GBM, but no significant MTA accumulation was detected in vivo because the stromal cells in the TME express WTAP and consume the MTA emitted by tumor cells and increase the activity of PRMT5