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Nausea is the most commonly reported side effect, and roughly one-quarter to one-half of people experience nausea, vomiting, diarrhea, abdominal pain, and/or constipation

He said one patient, who was originally downing about 45 alcohol drinks a week, had cut her consumption in half by taking naltrexone on the days she drank

Oral glutamine supplementation increases seizure severity in a rodent model of mesial temporal lobe epilepsy

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This suggests that many people may require ongoing drug treatment, unless they are able to make the necessary lifestyle changes to sustain their lower weight and improved metabolic health without medication