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Pemetrexed, a cytotoxic agent approved for treating non-SCC, is the current first-line treatment for LCC [158]
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Therefore, CK activity can be used as a surrogate marker for the leakage of these cellular metabolites, which confirms membrane rupture
Blood parameters evaluation All serum samples from Groups A and B were prepared and stored at 80C after centrifugation at 1500 g for 10 min and the levels of vitamin D3 and ferritin were measured using an automated biochemistry instrument (Cobas e411/Roche Company, Switzerland) according to the manufacturers instructions, whereas an automated hematology analyzer (Swelab alfa/Boule Medical AB, Sweden) was used to measure Hb levels
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