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The resulting increase in Treg abundance dampens metaflammation and reduces circulating and islet levels of TNF-, IL-1, and IFN-, which in turn alleviates -cell ER stress and protects against cytokine-induced apoptosis (Kaisar et al., 2017)

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Notwithstanding all of these experimental findings, to date there is not sufficient clinical evidence to justify the use of NRF-2 in medical practice