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By week 16, a larger proportion of AXA1125-treated subjects (3540%) than those in the placebo group (825%) reached clinically relevant thresholds for MRI-PDFF reductions of 30%, ALT reductions of 17 IU/L, and cT1 reductions of 80 ms

Shoshani O, Livne E, Armoni M, Shupak A, Berger J, Ramon Y, Fodor L, Gilhar A, Peled IJ, Ullmann Y

Published online January 12, 2023 DOI: 20,297 View 691 Download 57 Web of Science 60 Crossref Abstract PDFPubReader ePub Sarcopenia, defined as a progressive loss of muscle mass and function, is typified by mitochondrial dysfunction and loss of mitochondrial resilience

The iron-overload state commonly observed in AD brains exacerbates neuronal oxidative damage and, through the release of pro-inflammatory mediators and activation of immune cells, contributes to the structural disruption of the BBB